Topical application of doxycycline inhibits Th2 cell development mediated by Langerhans cells and exerts a therapeutic effect on atopic dermatitis
K Matsui, Y Nojima, Y Kajiwara… - … of Pharmacy & …, 2020 - journals.library.ualberta.ca
Background: Langerhans cells (LCs) polarize the immune milieu towards a T helper type
(Th) 1 or Th2 immune response. We investigated the effects of selected tetracyclines on Th
cells development mediated by LCs, and their implications for the treatment of atopic
dermatitis (AD). Methods: Mice were primed with ovalbumin (OVA) peptide-pulsed LCs,
which had been treated with each antibiotic, via the hind footpad. After 5 days, the Th1/Th2
cytokine response in the popliteal lymph nodes was investigated by enzyme-linked …
(Th) 1 or Th2 immune response. We investigated the effects of selected tetracyclines on Th
cells development mediated by LCs, and their implications for the treatment of atopic
dermatitis (AD). Methods: Mice were primed with ovalbumin (OVA) peptide-pulsed LCs,
which had been treated with each antibiotic, via the hind footpad. After 5 days, the Th1/Th2
cytokine response in the popliteal lymph nodes was investigated by enzyme-linked …
以上显示的是最相近的搜索结果。 查看全部搜索结果